Health - Conditions
By: - at June 16, 2013

How Unhealthy Diet Could Trigger Inflammatory Arthritis

Inflammatory arthritisThe way in which unhealthy diets are linked to inflammatory arthritis is a complex process but research shows that the intestinal wall, foreign proteins, and molecular mimicry are some of the contributing factors that can lead to inflammatory arthritis.

Diet has been linked to the development of certain forms of arthritis like rheumatoid arthritis with many patients showing improvement in their arthritic condition when they eliminate certain foods like dairy products. However, the way in which diet factors contribute to arthritis is complex and less understood. Some theories have tried to explain the intricate processes that occur when people susceptible to contracting arthritis ingest certain foods. Understanding the role diet plays in managing arthritis can help alleviate and minimize symptoms associated with this condition.

What is inflammatory arthritis?
Arthritis occurs when joints become inflamed due to an autoimmune response triggered by environmental elements. The inflammation of joints can occur due to many things such as injuries, diseases, bacterial infection, unhealthy foods, and the introduction of toxic substances in the body.

Inflammatory arthritis is a collective term that refers to autoimmune diseases involving the inflammation in joints. The body’s immune system can act abnormally causing the body to attack its own healthy tissue. Inflammatory arthritis can affect people of all ages and many who live with the condition may not show visible signs of the disease until it has progressed.

Arthritis conditionsAlthough a few arthritis conditions may be treated when the known causal factor is identified. Traumatic arthritis is caused by injuries sustained to the joints. Unfortunately, arthritis conditions of no-known-cause have no cure and can only be managed through different therapies. The cause of the arthritis determines the type of arthritis a patient is suffering from and treatment options.

If the condition is caused by a bacterial infection, it is termed as supparative arthritis. Gouty arthritis occurs when the body triggers an autoimmune reaction in response to an over accumulation of uric acid crystals. Also known as septic arthritis, people with artificial limbs and implants are at a much higher risk than the general population. Moreover, the arthritis conditions arising from no-known-cause are categorized into inflammatory and degenerative arthritis. Osteoarthritis is one example of degenerative form of arthritis while juvenile rheumatoid arthritis is a form of inflammatory arthritis. The most common forms of inflammatory arthritis include ankylosing spondylitis, rheumatoid arthritis, reactive arthritis, psoriasis arthritis, and systemic lupus erythematosus.

How the immune system can worsen arthritis?
The immune system helps in fighting foreign materials in the body such as bacteria, virus, parasites, fungus and other unwanted materials. The immune system is the whole function of many complex processes. It works by identifying foreign invaders and attacks them before they can cause harm to the body.

In order for the body’s immune system to work effectively, it should be able to differentiate between the “self” as well as “non self” cells, tissues, and substances. Usually “self” cells are not destroyed by the immune system. Nonetheless, “non self” substances are referred to as antigens. The proteins found on the surfaces of pathogens like bacteria, viruses, and fungi are antigens. When the proteins or antigens bind to special receptions released from the defense cells, this induces a series of cell activities that allow the immune system to recall memories stored in it and these reactions help in defending the body from known pathogens.

Healthy cells of the body also have surface proteins and they are not attacked by the immune system like other surface protein from foreign substances. This is because the immune system has already identified the specific cell proteins as self. However, in abnormal situations, the body’s immune system can mistakenly identify its own healthy cells as “non self”, thus triggering a condition known as an autoimmune reaction.

In arthritis conditions, the immune function works differently through autoimmune reactions. Instead of the immune system attacking the foreign substances it is intended to fight; it acts abnormally and attacks the healthy tissue of the body with no obvious reason. With arthritic patients, the autoimmune response leads to the invasion of joint tissues causing chronic pain and inflammation.

Ways in which unhealthy diets can trigger inflammatory arthritis
unhealthy diets can trigger inflammatory arthritisDiet plays a role in the development of arthritis but the mechanism surrounding the link between unhealthy diets and inflammatory arthritis is less understood. It is believed that complex processes involving the intestine and immune system are responsible for the development of inflammatory arthritis like rheumatoid arthritis. One of the aspects that have been associated with inflammatory arthritis is increased intestinal permeability. The intestinal lining provides a barrier that prevents intestinal content from entering the interior of the body.

In the stomach, there are large amounts of foreign proteins or antigens that originate from microbial activities and dietary intake. The intestinal mucosa turns large molecules into small ones in the process of absorbing and digesting nutrients. The intestinal mucosa runs from the mouth to the anus and provides a barrier that acts as the first line of defense against foreign substances. In addition, the mucosa also shows the body how it can handle food-related antigens that can trigger sensitivities and allergies.

When damage on the mucosa occurs, it can cause pathogens and unwanted foreign proteins to get to the interior of the body triggering an immune response. Only the smaller molecules are allowed to pass the intestinal wall and the large ones, which may act as antigens leading to immune response, are filtered and barred from passing through the mucosa lining.

When infections occur in the intestinal tract, they can cause gaps or openings on the mucosa wall, which leads to increased permeability. In the same way, toxins in body can also react with the mucosa, damaging its protective barrier. With the damaged mucosa, large molecules can pass to the blood and this is referred to as leaky gut or hyperpermeability.

Leaky gutA leaky gut is simply an increased permeability of the intestinal wall. A leaky or hyperpermeable gut allows toxins, undigested food, microbes, waste, and large macromolecules to pass across the gut wall. Sometimes the passing of certain substances or particles ca initiate an immune reaction. Although there are many things that can cause a leaky gut such as parasites, infections, toxins and medicines, poor diets are also known to contribute to this condition.

An unhealthy diet made up of primarily diary and animal products can cause inflammation of the intestinal wall, further increasing the passing of complex antigens from diet foods and bacteria to the blood stream. The gut contains large amounts of lymphoid tissue, which helps in protecting the body from antigens that are trying to pass through the intestinal wall.

When unhealthy diets formulated mostly of animal protein, fat, and cholesterol are eaten by a person, these food elements may compromise the ability of the lymphoid tissue to attack and destroy antigens. These antigens are trying to make their way into the interior of the body through the intestinal wall. The compromised lymphoid tissue allows the antigens to pass through the gut wall leading to an immune response.

Another way in which unhealthy diets are associated with inflammatory arthritis is through the presence of foreign proteins in body. When a leaky gut passes foreign proteins originating from food and bacteria, they end up in the blood. These foreign or unwanted proteins are recognized by the immune system as “not self”, meaning that they are regarded as invaders or foreign substances like the proteins from parasites, bacteria, and viruses.

What happens is that the body makes antibodies to fight these invading proteins and this triggers the immune response causing inflammation of joints. During the immune function, each antibody identifies and binds itself to a specific antigen the same way a key and lock fit into one another. In the body, antigen and antibody complexes can result due to leaky gut. A hyperpermeable gut can result to the body forming large complexes consisting of the foreign protein or antigens and the antibodies.

Although the body naturally removes these large complexes, it is believed that in some people, the rate at which the complexes are formed may be too rapid than they are removed meaning that they accumulate within the body. Usually the complexes are filtered by micro capillaries found in the kidney, skin, and joints and when they are stuck in the capillaries around the joints, they can cause inflammation to occur. This is the major cause of arthritis in adults.

Another theory that tries to explain how inflammatory arthritis may be triggered by unhealthy diet is molecular mimicry. When foreign proteins enter the body, they can cause the formation of antibodies, which may not be specific to a particular foreign protein and can easily interact with similar human proteins. To help understand how molecular mimicry plays a role in triggering autoimmune diseases like inflammatory arthritis, it is important to examine how the immune function works.

In the body, antibodies are created by B cells (a type of lymphocytes or white blood cells) in response to antigens such as foreign protection, nucleic acids, and polysaccharides. The two main types of lymphocytes or white blood cells are B cells and T cells. The B cells secrete antibodies into the body fluids, and these antibodies help invade foreign antigens that circulate in blood stream.

Because the B cells cannot penetrate other cells, the T cells have the ability to closely intermingle with their target cells meaning that they can attack body cells that have been invaded by viruses. The immune system identifies and recognizes a part of a foreign protein invading the body using the T cells. These T cells have receptors, which attach themselves to short parts of foreign proteins and they are helped in the task by macrophages.Macrophage and T Cells

The macrophages invade foreign proteins or food particles and break them down. Usually, microphages are antigen presenting cells, and help in showing T cells, which foreign proteins to be attached. In a molecular mimicry situation, the protein fragment presented to T cells by macrophages can contain parts that resemble each other but not identical. This tricks the immune system through the T cells to attack different proteins including self protein.

The body is made up of self proteins, which are recognized and not normally attacked by the immune system. However, when an autoimmune reaction occurs, the T cell attacks self proteins that are similar to those presented by the macrophages because they contain the same string of amino acids.

Research has shown that some parts of protein found in infection causing agents and foods also resemble parts of the self proteins of the body. Therefore, if certain self proteins in the body take similar molecular structure to those of complex foreign proteins, the immune system can be triggered to attack them and this is how joints are inflamed when a person consumes cow milk. This is because the cow’s milk has complex proteins that are similar to body’s self protein found in the joint cartilage.

In essence, the body’s defense system can be promoted by a healthy diet thus being able to remove antigens, which find their way into the interior of the body. The defense system can also remove immune-complexes found in the blood. When the right healthy diet is adopted, it can help minimized the complex processes that are associated with the immune system and development of inflammatory arthritis. Arthritis patients need to discuss with their doctors on the right diets to include in their foods as a way of managing and preventing the flare ups of arthritis conditions. A healthy diet enhances the immune system and improves the functional role of the intestinal walls, which is preventing foreign proteins of bacteria and foods origins from entering the interior of the body. A healthy intestinal wall promotes a healthy body by reducing chances of triggering autoimmune reactions that are responsible for many diseases such as Crohn’s disease, Scleroderma, and arthritis.





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